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During the degranulation and release, perforin polymerizes and forms pores in the target cell membrane to facilitate granzymes delivery into target cells, inducing apoptosis through different pathways, including caspases-3/7 activation, cytochrome C release from mitochondria driven by Bak/Bax, and IL-1 regulation by caspase-1 [32]

The diversity of plasticity in interneurons demonstrates the need for a generic homeostatic mechanism but also highlights a point of convergence of the requirements for plasticity induction: the rise of [Ca 2+ ] i

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