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The role of the innate immune system has recently come into play as well because investigators reported an upregulation in Toll-like receptor 4 signaling pathways in animal models of osteonecrosis, leading to activation of osteoclasts.103, 104 TABLE 103-4

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probiotics/prebiotics integrate readily with lifestyle programs, suit prevention and maintenance, and are easier to standardize, albeit with modest and variable effect sizes [242,243,244,245,246,247, 256,257,258]

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