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The most recent consensus statement from the International Microdialysis Forum, released in 2015, summarized key advances in the CMD clinical usage and contributions to neurocritical care since 2004 [25]

The exact mechanism of action is not known but several mechanisms are thought to be involved which include the blockage of macrophage receptors, the inhibition of antibody production, the inhibition of complement binding and the neutralization of pathologic antibodies

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This cross-talk ensures that hormonal adjustments, antioxidant defenses, and ion transport function synergistically to optimize stress resilience

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