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The strongest clinical signal sits with triglycerides and the total cholesterol-to-HDL ratio, both driven by visceral fat reduction rather than a direct pharmacological effect on lipids

Many natural and synthetic substrates used by laccases have an ortho -methoxy substituent on the phenol, an electron-donating moiety that facilitates oxidation 29

Accordingly, in certain embodiments, the subject in need thereof may be a subject identified as being a responder based on: [1] the subject having autism or ASD and having lower plasma and/or intracellular levels of GSH, tGSH, or both, as compared to a control group without a diagnosis of autism or ASD

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[DOI] [PMC free article] [PubMed] [Google Scholar] 168.Wang D., Buchanan F.G., Wang H., Dey S.K., DuBois R.N