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Evangelista I, Nuti R, Picchioni T, Dotta F, Palazzuoli A

However, there are still challenges that need to be addressed, such as the optimization of properties, reliable characterization methods, safety evaluation, nanoparticles that might lead to unintended consequences like nano-pollution and cytotoxicity and regulatory aspects related to nanomedicines targeting skin cancer [176, 179]

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On the other hand, a decrease in autophagy has been reported in several neurodegenerative disorders, which proposes that this process is a factor that contributes to protein accumulation and cellular toxicity due to problems in protein folding, as in AD (Menzies et al., 2011)

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