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Importantly, this quiescent or slow-cycling state remains reversible: upon drug withdrawal or relief of selective pressure, DTP cells can rapidly re-enter the cell cycle and restore proliferative capacity, clearly distinguishing them from senescent cells or terminally arrested populations that display stable growth arrest and irreversible phenotypic commitment ( The third central mechanism involves chromatin remodeling and epigenetic plasticity

10.1038/s41598-020-67104-4 Sci Rep 49 MoonR.ParikhA

Zhang N, Ping W, Rao K, Zhang Z, Li G, Ning S

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G-R: Data curation, Investigation, Writing review & editing