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Since SARS-CoV-2 activates mitochondrial ROS-mediated feedback loops that produce long-term changes in the redox status and endothelial function of the host, leading to cardiovascular disease and lung injury (Chang et al., 2021), and endothelial cells are key players in inflammatory pathologies, such as acute respiratory distress syndrome, thrombosis, and atherosclerosis

It is globally recognized that IgM provides a first line of defense during microbial infections, before a high affinity IgG adaptive immune response develops imparting lasting immunity and immunological memory

Conversely, curcumin dissolves in ethanol, Dimethyl sulfoxide DMSO, acetic acid, chloroform, acetone, and alkali (Moovsk et al., 2016)

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Thus, its protective effects overlap those of GPx-1