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A classic pharmacokinetic study in the Annals of Internal Medicine (Levine et al., 2004) found that a modeled 50 g IV dose produced peak plasma levels around 13,400 mol/L, versus 220 mol/L for the maximum tolerated oral regimen roughly 3070 times higher plasma concentrations with IV administration

Some laboratory tests that can be beneficial are cortisol levels, a comprehensive wellness panel, hormone tests, sleep & stress tests, thyroid panel, and inflammation tests

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doi: 10.1038/356215a0 94 WangSJLiDOuYJiangLChenYZhaoYet al

Mechanisms are oversimplified