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By facilitating the removal of protein aggregates, paeoniflorin may reduce one source of toxicity in PD

By engineering a patients T-cells to specifically recognize senescence-associated surface antigens, CAR-T therapy achieves highly precise targeting of SnCs

In addition, as PAH mediates the conversion of phenylalanine (Phe) to tyrosine (Tyr), hyperphenylalaninemia (HPA) is present in all BH 4 deficiencies apart from autosomal dominant guanosine triphosphate cyclohydrolase I deficiency (AD-GTPCHD) and sepiapterin reductase deficiency (SRD) [1, 2]

Similarly, treatment of NSD2 HiBit cells with 1 M UNC10415667 for 6 h resulted in a reduction of NSD2 levels by about 75% (Fig