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In terms of metabolic pathways, ASIV upregulates prolyl hydroxylase 2 (PHD2) to promote the degradation of HIF1, blocks the HIF1/NLRP3 inflammasome pathway to inhibit pyroptosis of PASMCs, and downregulates the transcription of the downstream fibrotic factor Collagen I of HIF1 (Jin et al., 2021

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doi: 10.1155/2021/9959807 70 WangYCXieHZhangYCMengQHXiongMMJiaMWet al