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"Chasing the Chinese dream"

Topical administration of up to 10 mg/kg is well tolerated, whereas intravenous doses above 1 mg/kg may induce systemic toxicity (Yuan et al., 2022

The renal excretion of creatinine is regarded as relatively constant over the day in healthy individuals, allowing to calculate metabolite/creatinine ratios, typically presented as g metabolite per gram of creatinine (g/g creatinine) (Johner et al

(2014) 146:789800.e8

HepG2 xenograft-tumor model Twenty-five pathogen-free female BALB/c nude mice, 45 weeks of age, were purchased from the Guangdong Medical Laboratory Animal Center