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In the tumor microenvironment, TNF downregulates SLC7A11 to activate CD 8+ T cell ferroptosis, which facilitates T cell exhaustion and thus contributes to tumor cell survival[57]

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On the other hand, depletion of optic atrophy 1 (OPA1), the mitochondrial dynamin-like GTPase controlling membrane fusion and cristae formation, decreases complex IV activity and function, impaired insulin release and ATP synthesis, and impaired -cell proliferation and mass (Zhang et al., 2011)

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