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Subsequent in vivo and in vitro experiments confirmed that the transmembrane protein 164 ( TMEM164 ) gene might be mainly involved in the positive regulation of IMF deposition and have a certain negative regulatory effect on AF deposition

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EDMD is primarily manifested with early childhood-onset limb weakness, muscle atrophy, contractures affect neck, elbow, and ankle, and adult-onset arrhythmia, increased risk of sudden cardiac death

Ran et al., 2021)