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Lactoferrin functionalized PEG-PLGA nanoparticles of shikonin for brain targeting therapy of glioma

The Solution: Cerebrolysin

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These alterations increase the NADH/NAD+ ratio, which inhibits Complex I activity and promotes electron leakage to oxygen, generating additional superoxide radicals and intensifying oxidative injury (130)

The highest prevalence was observed in the northeastern part of the country (5.0%), followed by areas in the northern part (1.8%), while a lower prevalence was observed in the central (0.9%) and southern parts of the country (0.1%) (41)