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Yet hormonal changes can be complex: Men who begin GLP-1 therapy may initially experience a small dip in testosterone as body fat decreases, since adipose tissue helps regulate conversion of testosterone to estrogen

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Although these models have yielded invaluable insights into core pathways like pyroptosis and ferroptosis, they fail to fully recapitulate human pathophysiology due to species-specific differences in thermoregulation, inflammatory response kinetics, and hepatocyte metabolism

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Food components modify the diversity and abundance of the microbial populations, maintain the integrity of the gut barrier, and regulate the passage of microbes and their metabolites into the blood stream where they modulate the immune system and communicate with body systems including the brain