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Persistent TCM Methodological Hurdles: Inherent complexities in TCM research, including unclear bioactive components, poorly understood multi-component synergistic mechanisms, and challenges in ensuring reliable experimental interventions and placebo controls, continue to pose substantial obstacles, raising concerns about the reproducibility of findings and hindering mechanistic understanding

Cirelli Mediators of Inflammation.2020

In a four-month crossover, double-blind, placebo-controlled trial, perimenopausal women taking 2 g of Maca-GO for two months had statistically significant increases in E2 and P [27]