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All patients showed a tendency of improvement of clinical manifestations by week 54 of combined MT + IF treatment: reduction of joint syndrome intensity, time of morning stiffness, pain and swelling of the affected joints, which was expressed in reduction of patient-defined VAS indices (on average, from 66.7 to 18.4 mm) and DAS28-CRP(4) (on average, from 5.5 to 3.03)

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These results are consistent with PET findings of a reduction in cerebral glucose metabolism in the brains of depressed patients (Baxter et al., 1989), which was reversed by 6 weeks of treatment with the SSRI paroxetine (Kennedy et al., 2001)

(Qassim) , 2013 , 7 (3), 267-275