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Although research data indicate a great potential to target the gut microbiota in contributing to treatment of hypertension by using probiotics, changing lifestyle, and diet, further research is warranted to better understand the role of various gut microbial species and their metabolites in the regulation of blood pressure and associated diseases

For instance, lead exposure triggers oxidative damage and impairs synaptic transmission, while zinc toxicity is associated with increased reactive oxygen species (ROS) and disruption of metabolic enzyme activity [30]

2017;96(32): e7773

The center of the rosettes sometimes contains amphophilic material or small, endothelium-lined vessel