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Pathway and process enrichment analysis was then used to identify common differentially regulated pathways or processes in A2780 and A2780/GSTP1 cells (Supplementary Table 2)

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Among these, accumulation of p62, also known as sequestosome 1 (SQSTM-1) and A170 (119), sequesters Keap1 into aggregates, resulting in the inhibition of Keap1-mediated Nrf2 ubiquitination and its subsequent degradation by the proteasome (120)

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