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These symptoms occur because vitamin B12 plays a critical role in the nervous system

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In another example, cyclophilin D, an important component of mitochondrial permeability transition pore, was observed to be overexpressed and oxidatively modified when stimulated by oxidative stress in affected brain tissue and skin-derived fibroblasts from patients with X-ALD as well as the spinal cord of X-ALD mouse models

Bischoff et al

Binder RE, et al