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392,393 Iron accumulates in the parenchymal cells of various organs in HH patients, generating ROS through the Fenton reaction, resulting in ferroptosis and several serious chronic complications, including heart disease, diabetes, and cirrhosis

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V., and Andexer, J

(2016) prepared MSCs overexpressing CXCR4 (CXCR4-MSCs) via lentiviral transfection, enhancing MSC migration and improving the efficiency of intervertebral disc (IVD) regeneration

Moreover, glutamine-induced activation of mTORC1 results in the phosphorylation of the enzyme complex called carbamoyl phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD), which catalyzes the condensation reaction converting glutamine-derived nitrogen into the pyrimidine precursor orotate 34,35