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Movement across the BBB occurs via transmembrane efflux pumps (Abbott et al., 2010) that transport molecules through endocytosis or through pores, carrier-mediated transport systems, or through direct permeation through the plasma membrane via lipophilic molecules (Banks and Kastin, 1992)

Its a 15-amino-acid peptide originally derived from a protective protein naturally found in human gastric juices, and it has been studied for more than 30 years by multiple independent research groupsmost notably teams in Croatia and Taiwan

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With this characteristic, liposomes exhibit an excellent protective effect for the drug, as the aqueous phase stabilizes the polar segment, along with shielding the nonpolar segment of the drug