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39 H evidncias em quantidade suficiente e de qualidade moderada alta de oito estudos clnicos randomizados com duloxetina (2.728 pacientes), nas doses de 60 mg e 120 mg por dia, mostrando eficcia no tratamento da NPDD no curto prazo, com razo de risco (RR) para reduo da dor 50% em 12 semanas [RR 1,73 (IC 95% 1,44 a 2,08)] e um NNT = 5,0 (IC 95% 4 a 7)

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Physiological parameters were measured by 0, 4 and 7 days, and iTRAQ was measured by the day 7

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