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In addition, since 2006, thalidomide as a type of biological therapy in combination with dexamethasone has been approved for the treatment of newly diagnosed MM patients [70]

Injectable lipid-based nanoparticles and polymeric systems have already demonstrated the capacity to maintain therapeutic plasma drug concentrations for weeks to months, thereby minimising adherence-related failures [140]

In vitro isobologram analysis The effects of tamoxifen alone and in combination with rotenone on the proliferation of drug-sensitive (AuxB1 and MDA-MD-231) and resistant (CHO R C5 and MDA-Doxo 400 ) cells were assessed using the modified fixed-ratio isobologram analysis protocol