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By reframing stroke within a vascular-metabolic continuum, MRIS shifts the paradigm from a neuron-centric view to one of systemic bioenergetic failure, accounting for past translational gaps and opening pathways for precision therapies, from pentose phosphate pathway modulation to nanoparticle-based metabolite delivery and microbiome interventions

10.1002/ejp.1207 Eur

Note - if you want to ensure you have optimal Choline levels in your body, you may want to take substances that impede Choline breakdown such as Ginkgo and Bacopa monnieri 51

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Preliminary data on cows reared in polluted areas show increased expression of e-GST that parallels the results found for humans