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This can limit the effect of bromelain in degrading the tumor ECM due to the short half-life of bromelain in the blood

Science 322:587590 Ren C, Du A, Li D, Sui J, Mayhan WG, Zhao H (2010) Dynamic change of hydrogen sulfide during global cerebral ischemiareperfusion and its effect in rats

J Gerontol A Biol Sci Med Sci 69(Suppl_1):S4S9 Freitas RH, Fraga CA (2018) NF-B-IKK pathway as a target for drug development: realities, challenges and perspectives

Cell 44 (1), 134146

In this context, supplementation with ALA would undoubtedly support GPx activity by maintaining sufficient intracellular GSH pools, thereby leading to the significant enhancement of GPx expression following CSD as compared to other relatively unchanged anti-oxidative enzymes