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10.1152/physrev.00036.2024 56 LanD.HuangS.LiJ.ZhouS.DengJ.QinS.et al (2025)

The addition of NAC helps support the bodys natural glutathione production, while milk thistle contributes to liver health and detox support

These data provide further validation to the SAFE score as an indicator of clinically significant liver fibrosis, which may be useful in screening for potential candidates for liver-directed therapy for MASLD

As shown in Figure 5F, there was almost no GSTP-S42A, GSTP-S42D, GSTP-Y198F, or GSTP-Y198D protein in the nucleus of LPS-unstimulated cells, and all GSTP mutant proteins appeared in the nucleus after LPS stimulation