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Zhao H, Guo L, Zhao H, Zhao J, Weng H, Zhao B

Characterization of the metabolic interactions between folate and methionine in the regulation of SAM-dependent homocysteine levels, as assessed by Selhub and Miller (Miller et al, 1994a, 1994b

One study of 48 children (mean age 7 years and 4 months) with ASD and language impairment split patients into two groups, one received 2mg/kg/day (up to 50mg max) leucovorin calcium (folinic acid calcium salt), the other received placebo

Diagnosis is made by measuring the concentration of different metabolites in the gamma-glutamyl cycle, enzyme activity and in glutathione synthetase and gamma-glutamylcysteine synthetase deficiency, also by mutation analysis

L., & University of Rochester Cancer Center Community Clinical Oncology Program