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2018;10:73-95 [2] Soules MR, Sherman S, Parrott E, Rebar R, Santoro N, Utian W, Woods N

The C5a/C5ar1 Axis promotes progression of renal Tubulointerstitial fibrosis in a mouse model of renal ischemia/reperfusion injury

ferroptosis-related genes (GPX4 and ACSL4) serve as prognostic biomarkers (233), supporting precision therapy development

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Thus, investigators use small animal models that, along with studies in human cell cultures and overdose patients, are thought to most closely represent what occurs in human beings