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However, other pathophysiological modifications within melanoma cells may contribute to therapy resistance [4, 5], demanding for large-scale computational models to simulate the complex physiology of a tumour in an integrated manner and comprehensively foster the identification of alternative therapeutic vulnerabilities applying high throughput in silico approaches [6, 7]

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LC/MS=515 [M+1]

Relative protein expressions were detected by chemiluminescence using the ECL kit (Thermo Fisher Scientific, USA)

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