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doi: 10.1016/j.immuni.2013.04.005 192 O'NeillLAJPearceEJ

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It is possible that circulating IGF-II after release from the ternary complex is cleared from the circulation by binding to the IGF2R identical to the mannose-6-phosphate receptor which is associated with lysosomes and results in degradation of IGF-II in endothelial cells (23)