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Nelumbo nucifera (lotus leaf) can clear heat-dampness and ascend and invigorate yang-qi.Its bioactive component, nuciferine, is a tetracyclic aporphine alkaloid that can effectively reduce renal lipid accumulation by regulating AMPK-mediated expression of FAS and hormone-sensitive triglyceride lipase (HSL) and inhibit inflammation and oxidative stress through the AMPK-mediated Nrf-2/HO-1 and TLR4/MyD88/NF-B pathways [125]