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Selenium-dependent glutathione peroxidase protein and activity: immunological investigations on cellular and plasma enzymes

C.De MicheleR.JonesR

Therefore, targeting iron metabolism disorders, lipid peroxidation accumulation, and osteoblast ferroptosis in subchondral bone may provide new therapeutic strategies for OA

There is also increasing evidence that deregulation of GSH synthesis contributes to the pathogenesis of diseases such as diabetes mellitus, pulmonary and hepatic fibrosis, alcoholic liver disease, cholestatic liver injury, endotoxemia, and drug-resistant tumors cells [10]