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DSIP was first characterized by Marcel Monnier and colleagues at the University of Basel, Switzerland, arising from a series of cross-circulation experiments in which blood from a sleeping rabbit was transferred to an awake recipient, causing measurable changes in the recipient's EEG brainwave patterns consistent with delta-wave sleep induction

Three things, and they deserve fair hearing

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What the broader literature describes is remodeling, not a one-way pile-up

Driven by the Haber-Weiss and Fenton reactions [Table 2], excess copper ions initially generate hydroxyl radicals, which subsequently convert copper into highly reactive intermediates (peroxyl, hydroperoxyl, and superoxyl species)