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Datta and Chattopadhyay, 2015)

Available from: Murphy EJ, Rezoagli E, Major I, Rowan NJ, Laffey JG

Its catabolism is closely linked to the progression of fibrosis [168]

E3 ligases in metabolic diseases Insulin receptors and insulin receptor substrates (IRS-1 and IRS-2) are crucial for insulin signaling, and E3 ligases such as MG53, c-Cbl, and Nedd4 can directly degrade these substrates, disrupting signaling and promoting insulin resistance