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Despite their efficacy, long-term LD use is associated with motor complications, prompting the development of novel therapies such as adenosine A2A antagonists (istradefylline), which reduce OFF episodes, and GLP-1RAs, which show neuroprotective potential

When labs indicate that a patient needs systemic support beyond what peptides alone address, we coordinate with their gynecologist, endocrinologist, or primary care physician rather than prescribing outside our lane

These analogues have been utilized in various biochemical, structural, and functional studies

doi: 10.1002/art.24751 40 UrregoTOrtiz-ReyesBVanegas-GarciaALMunozCHGonzalezLAVasquezGet al