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Furthermore, peripheral estrogen hydroxylation was found to be increased in both men and women with SLE and estrogenic metabolites were reported to increase B cell differentiation and activate T cells [44]

Sebecic B, Nikolic V, Sikiric P, et al

Mechanistically, oxidative stress triggers endoplasmic reticulum stress through the activation of the PERK-eIF2-ATF4 and IRE1-XBP1 signaling pathways, as well as through the upregulation of CHOP (C/EBP homologous protein), which promotes apoptotic signaling (75) as shown in Figure 4

Talk to your doctor or genetic counselor if you have questions about genetic testing for CTD

Zitka, O