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Gins P, Krag A, Abraldes JG, et al

Gut microbiota-derived succinate aggravates acute lung injury after intestinal ischaemia/reperfusion in mice

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We hypothesize that the brain energy gap, first described by Cunnane et al., [39] explains the increased susceptibility to developing delirium in the elderly critically ill patient population with preexisting cognitive impairment, and that exacerbation of this brain energy gap as a result of delirium contributes to the progression of preexisting cognitive impairment that is often apparent once delirium resolves (Fig