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PMID: 28028523

Kessler, S

J Cell Mol Med (2018) 22(3):197283

Modifying a drug delivery system with a brain targeting agent has been an effective approach in developing a brain targeting drug delivery system

Mechanistically, hypoxic/glycolytic tumor niches boost glucose metabolism in CD71 + neutrophils, leading to increased lactate production and subsequent histone lactylation, but not histone acetylation, at the Arg1 promoter, resulting in T cell suppression