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Numerous mechanisms 15 have been proposed, including mechanical injury caused by severe motion of the basilar membrane, metabolic exhaustion of activated cells, activity-induced vascular narrowing that causes ischemia, and ionic poisoning from interruption of the normal chemical gradients of the cochlea owing to minuscule disruptions in the organization of sensory and supporting cells

A variety of factors may determine glutathione requirements, including level of exposure to toxins, increased phase I detoxification activity, and overall need for antioxidant support

The experimental results (Fig

Knockdown of ANT2 reduces adipocyte hypoxia and improves insulin resistance in obesity

MOSLEY: You write about this about this