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Centrally, it crosses the bloodbrain barrier to engage GLP-1 receptors in the arcuate nucleus and brainstem, modulating POMC neurons and other appetite-regulatory circuits to reduce food intake and cravings

doi: 10.1038/nm.2014

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However, proteolysis can also lead to the formation of bitter-tasting amino acids such as arginine, histidine, isoleucine, leucine, methionine, phenylalanine, tyrosine, and valine [5,37]