Sdu Journal of Health Sciences 10:4 Fernando RA, Fennell TR, Watson SL, Silinski MAR, Blake JC, Robinson VG, Waidyanatha S (2022) Development and validation of an analytical method for quantitation of Alpha-pinene oxide in rodent blood and mammary glands by GC-MS
Lu GD, Shen HM, Chung MC, Ong CN
While electrostatic repulsion from phosphate group addition is known to disrupt protein-nucleotide interactions 103 , our data indicates that S114 phosphorylation does not alter binding by the nuclear export receptor, XPO-1
doi: 10.3389/fimmu.2021.626199 43 LaurensMB
It reduces the activity of tyrosinase by three different mechanisms: (i) chelation of the copper site by its thiol group, (ii) interfering with the cellular transfer of tyrosinase to premelanosomes which is a prerequisite for melanin synthesis, and (iii) indirectly via its antioxidant effect.[] Glutathione shifts melanogenesis from eumelanin to phaeomelanin synthesis by reactions between thiol groups and dopa-quinone leading to the formation of sulfhydryl-dopa conjugates.[] It has also been found to be scavenger of UV radiation-induced reactive oxygen species generated in epidermal cells.[] METHODS This was a prospective comparative study to assess and compare the therapeutic efficacy of localized TA and glutathione for treatment of facial melasma over a period of 18 months (December 2017 to May 2019) conducted in department of dermatology on OPD basis in a tertiary care center
