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When used appropriately and under medical supervision, melatonin supplementation can improve sleep latency and duration, particularly in cases of jet lag, shift work sleep disorder, and delayed sleep-wake phase disorder (DSWPD)

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These reactive molecules can also form DNA adducts, which under repair impairment can lead to mutations and other genetic abnormalities

Mitochondrial UQCRC1 mutations cause autosomal dominant parkinsonism with polyneuropathy