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It is a moisturizing antioxidant that plays a role in picking up free radicals and protecting the skin from damage & breakouts, as well as supporting skin repair

While a dominant-negative effect might have been anticipated, heterozygous mice are normal, while homozygous mice have severe defects of cornea, mildly impaired growth, skin fragility, and mild skin extensibility a substantially different phenotype from classical EDS due to COL5A1 haploinsufficiency

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87 However, aspirin disrupts the normal degradation of -catenin by interfering with the destruction complex, including Axin, APC, GSK3, and PP2A