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Although mitochondria have antioxidant defenses like SOD, which helps convert superoxide anions into less harmful molecules, too much mitochondrial ROS can cause oxidative stress and harm both the mitochondria and the sperm cell

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In vitro studies have confirmed that molecular oxygen, superoxide, and H 2 O 2 all have the capacity to oxidize thiols, and among these H 2 O 2 stands out (Winterbourn and Metodiewa, 1999