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53 MillerD

Delrot & H

Various studies have shown that gut microbiota dysbiosis is closely related to PDAC, with potential mechanism involving immune regulation, metabolic process impact, and reshaping the tumor microenvironment

However, these methods capture only a portion of the complexity of cellular regulation, as a substaintial fraction of human biology is governed at the proteome level through PTMs, which dynamically modulate protein structure, function and interactions in ways not captured by genetic approaches