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Inadequate absorption or utilisation of Vitamin B12 because of age, gastric abnormalities such as Coeliac disease, inflammation of the stomach or intestines, after stomach and bowel surgery, and inflammatory bowel diseases (Crohns disease)

The pathological effects of oxidative stress underscore the importance of developing therapeutic strategies aimed at reducing ROS levels and enhancing antioxidant defenses to improve male fertility outcomes

Moreover, since recent studies have shown that the de- and remyelination extend as well the cellular composition seems to differ between white and gray matter MS lesions (Bo et al., 2003