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Zhang Z, Zhao L, Zhou X, Meng X, Zhou X

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1e, f) suggested placement of polar and non-polar substituents in multiple locations, including those that were relatively remote, we intentionally limited the modifications to those in proximity or to the putative chimera molecule itself to maximize the potential for further improvements during structure-activity relationship (SAR) studies

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Indeed, an optimized Fer-1 molecule with an improved ADME (absorption, distribution, metabolism, and excretion) profile is expected to move into preclinic and clinic trials [115]