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4.1 Revisiting classical pathways: context-dependent roles of Nrf2 and HDAC inhibition SFN activates the Nrf2 pathway through covalent modification of specific cysteine residues (Cys151, Cys273, and Cys288) on the Keap1 protein, leading to Nrf2 stabilization, nuclear translocation, and transcriptional activation of cytoprotective genes including NAD(P)H quinone oxidoreductase 1 (NQO1), heme oxygenase-1 (HO-1), and glutathione biosynthesis enzymes (63)

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These bispecific constructs, characterized by their small size, high solubility and extended half-life facilitated by the integration of an albumin-specific sdAb, have demonstrated potent cytotoxicity against tumor cells, exceeding the ADCC of Daratumumab [94]

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