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Nevertheless, decreased levels of fibrinogen and prolonged PT represent the most reliable parameters for predicting bleeding.1619 Acute promyelocytic leukemia treatmentSupportive measuresAll-trans retinoic acid initiation for suspected acute promyelocytic leukemia ATRA should be initiated immediately after the minimum suspicion of APL diagnosis to counteract the disease-associated risk of bleeding

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10.1016/j.ajpath.2016.02.004 9 DikicI.ElazarZ

PSEN1E9, APPswe, and APOE4 Confer disparate phenotypes in human iPSC-derived microglia